The following categories of applicants are invited to apply:

• United States Small Business Concerns (SBCs) – organized for profit, with a place of business in the U.S., operating primarily in the U.S. or making a significant contribution to the U.S. economy; with no more than 500 employees including affiliates
• Joint ventures that qualify as U.S. SBCs – JV must be in an allowable legal form and include less than 50% participation by foreign business entities; each JV party must meet SBA ownership requirements for SBIR/SBCs and comply with 13 CFR §121.705(b) where applicable
• U.S. SBCs majority-owned and controlled (>50%) by U.S. citizens or permanent resident aliens, or by other qualifying U.S. small business concerns
• U.S. SBCs majority-owned by an Indian tribe, Alaska Native Corporation (ANC), or Native Hawaiian Organization (NHO), or a wholly owned business entity of such tribe/ANC/NHO
• U.S. SBCs majority-owned by multiple venture capital operating companies (VCOCs), hedge funds, or private equity firms (SBIR-only); no single VCOC/hedge fund/private equity firm may own >50% unless that single firm itself qualifies as a U.S. SBC owned/controlled by U.S. individuals

• National Institutes of Health

• Small Business Technology Transfer (STTR) Grant Applications for Minority Health and Health Disparities
• NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
• Notice of Special Interest (NOSI): SBIR/STTR Program Priorities to Bridge Gaps in Advancing the NIMH Mission
• SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Not Allowed)
• Small Business Innovation Research FY2025 Phase II