This grant opportunity seeks research focused on understanding how the immune system develops, functions, and is regulated in mice with different types of microbial exposure. Researchers may compare mice raised in special pathogen-free (SPF) environments to those exposed to a variety of microbes. They can also conduct in vitro (in a controlled environment outside a living organism) and ex vivo (outside the organism but in its natural environment) studies and assess immune responses to pathog… Show More

This NOSI aims to stimulate research to characterize immune system development, regulation, and function in mice with diverse microbial experience. Research approaches include comparison of SPF mice to animals with diverse microbial exposure, in vitro and ex vivo assessments, evaluation of immun… Show More